Bolstering to the validity of our CpG selection each gene has strong biological plausibility for association with MetS including roles in fatty acid metabolism (CPT1A) [17], lipid homeostasis and metabolism (SREBF1 [18], ABCG1) [19], skeletal endocrine regulation of metabolism (PHOSPHO1) [20], cytokine signaling (SOCS3) [21] and oxidative stress (TXNIP) [22]. This evidence concerns the gene TXNIP and metabolic syndrome.