Similarly, the CD8+ T-cell epitopes predicted for the S protein (aa505-520, aa755-765, aa873-881, and aa1209-1217), N protein (aa66-74, aa102-110, and aa343-369), and M protein (aa54-62, aa64-72, and aa172-180) have been experimentally validated using PBMCs of patients with COVID-19 (Table 6) [17, 67, 85]. This evidence concerns the gene CD8A and COVID-19.