Among 75 upregulated genes (S1 Table), we found that knocking down of JhI-21 (a LAT1 homolog[19]), minidiscs (mnd, a y+LAT1 homolog), cacophony (cac, a voltage-gated calcium channel) or Calmodulin (Cam) significantly suppressed RasV12/scrib-/- or RasV12/dlg-/- tumor growth (Fig 1g, quantified in Fig 1o; S1g Fig). The gene discussed is SCRIB; the disease is neoplasm.