RHEB and neoplasm: In addition, blocking mTOR signaling by knocking down of an upstream regulator of mTOR signaling Rheb[24] significantly suppressed RpS6 phosphorylation in RasV12/dlg-/- tumors (Fig 3e, compare to S3f Fig, quantified in Fig 3f) and tumor growth (Fig 3i, compare to Fig 3j, quantified in Fig 3k), while Rheb knockdown alone did not affect tissue growth (Fig 3h, quantified in Fig 3k).