SCRIB and neoplasm: Although the stronger JhI-21 knockdown (HMS02271) suppressed growth of wild-type clones (Fig 1m’ and 1n’, quantified in Fig 1o), which suggests that JhI-21 is essential for normal tissue growth, it completely abolished tumor growth and invasion of RasV12/scrib-/- or bantam/rab5-/- tumors (Fig 1j’, compare to Fig 1g’, quantified in Fig 1o; Fig 1l, compare to Fig 1b; S1j Fig, compared to S1h Fig, quantified in S1l Fig) and rescued lethality of animals bearing these tumors (Fig 1k, compare to Fig 1h and 1i; S1k Fig, compared to S1i Fig).