Here, using fruit fly Drosophila as a model organism, we searched for a common oncogenesis pathway between two malignant tumor models with different oncogenic alterations, namely oncogenic Ras activation with cell polarity defects (RasV12/scrib-/-) and oncogenic microRNA bantam overexpression with endocytic defects (bantam/rab5-/-). The gene discussed is SCRIB; the disease is neoplasm.