It has been reported that EBV nuclear antigen 1 (EBNA1) destabilizes the p53 gene to suppress p-53-mediated apoptosis [22, 23], and also EBER-1 induces the expression of insulin-like growth factor-1 (IGF1), which causes the autocrine action, promoting proliferation of the EBV-infected cancer cells [18, 24]. Here, TP53 is linked to cancer.