To strengthen the clinical significance of ZHX2, we also performed immunohistochemistry (IHC) staining in 20 pairs of normal/tumor TNBC patient parafilm tissue slides and found an overall increased ZHX2 staining in the TNBC tumors, especially in the nuclear staining by quantification (Figure 1G, H), suggesting overall and the nuclear located ZHX2 is upregulated in tumors from TNBC patients. Here, ZHX2 is linked to neoplasm.