Since ZHX2 was similarly reported as an oncogene in ccRCC and preferentially upregulated the transcription of downstream genes (Zhang et al., 2018), we focused on the 3969 ZHX2 positively regulated genes (downregulated following ZHX2 silencing by shRNA) as these genes may be more relevant in breast cancer. This evidence concerns the gene ZHX2 and breast carcinoma.