VHL and nonpapillary renal cell carcinoma: In addition, our recent findings through genome-wide screening identify that ZHX2 is a substrate of von Hippel Lindau (gene name VHL, protein name pVHL) protein, accumulates in kidney cancer, and promotes oncogenic signaling by at least partially activating nuclear factor κB (NF-κB) signaling in clear cell renal cell carcinoma (ccRCC) (Zhang et al., 2018).