ZHX2 and nonpapillary renal cell carcinoma: Since ZHX2 was similarly reported as an oncogene in ccRCC and preferentially upregulated the transcription of downstream genes (Zhang et al., 2018), we focused on the 3969 ZHX2 positively regulated genes (downregulated following ZHX2 silencing by shRNA) as these genes may be more relevant in breast cancer.