PIK3C2A and liver disorder: Through week 12, the frequency of AEs of special interest (AESIs) in the UPA 15 mg group was generally similar compared with the PBO group, with the exception of serious infection, HZ, hepatic disorder, neutropenia, and creatine phosphokinase (CPK) elevation, which were reported in a higher percentage of patients in the UPA 15 mg group (Table 3).