TP53 and infection: As well as infection, the p53 network responds to, and influences, many fundamental responses of cells to changing environmental conditions (e.g. nutrient deprivation; changes in pH, temperature, oxygen levels, osmolarity and radiation exposure) by inducing survival, repair, proliferation, senescence, differentiation or cell death programmes and by modulating immune cell function and surveillance affecting the biology of the entire organism (Fig 1).