Studies using gastric cancer cells treated with recombinant human TNF either alone or in combination with 5‐flurouracil resulted in reduction of Δ133p53 levels and an induction of p53α resulting in apoptosis (Shang et al, 2015), suggesting Δ133p53 may function to inhibit/moderate p53α‐promoted, TNF‐induced apoptosis. The gene discussed is TNF; the disease is gastric cancer.