TP53 and cancer: In addition, p53‐null mice show increased susceptibility to inflammation, auto‐immunity and cancer (Donehower et al, 1992; Okuda et al, 2003; Zheng et al, 2005; Guo et al, 2017) and various studies have shown that loss of p53 in myeloid cells can promote an immunosuppressive environment (Lowe & Ruley, 1993; Zheng et al, 2005; Guo et al, 2017).