Interestingly, increases in Ly6Chigh monocytes and monocyte-derived macrophages accompanied by a reduction in alveolar macrophages (AMs) in the TME of advanced KRAS/TP53 lung tumours have been reported recently (Casanova-Acebes et al., 2021), suggesting that a switch from AM-like TAMs to monocyte-derived TAMs is a common feature of TAMs during lung adenocarcinoma progression in mouse models. This evidence concerns the gene KRAS and lung adenocarcinoma.