We infected Kras+/LSL−G12D mice with the Ad5-mSPC-Cre adenoviral vector (Kamata et al., 2020; Sutherland et al., 2014) and allowed premalignant adenomas to develop for 8 months (Fig. 3A) (Kamata et al., 2020). The gene discussed is NLRP1; the disease is adenoma.