AKT1 and neoplasm: In contrast to intratumour MAC2+ cells that were negative for P-AKT, peri-tumour MAC2+ round cells were mostly P-AKT+ (Fig. 6D), suggesting that atorvastatin inhibits P-AKT in intratumour TAMs, but not in peri-tumour monocytes/M-MDSCs accumulated by extravasation through tumour microvessels.