CLCC1 and lung adenocarcinoma: However, as CLCC1 mutations are rare in human lung adenocarcinoma (0.35%, TCGA PanCancer Atlas; https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga) and they have an even distribution pattern (COSMIC; https://cancer.sanger.ac.uk/cosmic), we did not consider Clcc1 mutations as secondary drivers.