SARM1 is a compelling target for therapeutic intervention, as loss of SARM1 is profoundly protective in animal models of multiple neurodegenerative diseases including nerve injury, peripheral neuropathies, traumatic brain injury, glaucoma, retinitis pigmentosa, and Leber congenital amaurosis (Geisler et al., 2016; Gerdts et al., 2013; Henninger et al., 2016; Ko et al., 2020; Osterloh et al., 2012; Ozaki et al., 2020; Sasaki et al., 2020b; Turkiew et al., 2017). This evidence concerns the gene SARM1 and neurodegenerative disease.