HMOX1 and brain ischemia: A large accumulation of data has demonstrated that leukocytes infiltration could also occur inside liver after brain ischemia reperfusion, accelerating the body to discharge more inflammatory factors, producing more reactive oxygens species (ROS) thus exacerbating the redox imbalance, intensifying endoplasmic reticulum (ER) stress and increasing the expression of heme oxygenase‐1 (HO‐1) in liver, which ultimately results in more bilirubin entering into bloodstream.27, 28, 29, 30