The PIEZO1 E756del variant was also associated with resistance to erythroid invasion by malarial parasites in vitro and in mice,11 a finding subsequently confirmed by the association between the PIEZO1 E756del and decreased severity of Plasmodium falciparum malaria in human patients, possibly reflecting decreased red cell surface expression of the plasmodial virulence factor, PfEMP.13 The gene discussed is PIEZO1; the disease is Plasmodium falciparum malaria.