Supporting this notion, we recently found that genetic deletion of Notch receptors 2 and 3 in MM cells or treatment with GSI significantly decreases Rankl expression and impairs their ability to stimulate osteoclastogenesis[58], Rankl expression in MM cells is also stimulated by stromal cells, an effect depending on Notch activation[98]. This evidence concerns the gene TNFSF11 and Miyoshi myopathy.