AGT and Alzheimer disease: In addition, knockout of vascular smooth muscle cell-specific E-prostanoid receptor 4 gene induced AD in angiotensin II-infused mice with severe degradation of aortic elastic fiber, smooth muscle cell dedifferentiation, increased vascular NADPH oxidase 1 activity, reactive oxygen species generation, macrophage infiltration, matrix metalloproteinase-2/9 levels, and monocyte chemoattractant protein-1 expression, and higher blood pressure (7).