Studies reported that blood levels of cytokines and/or their receptors, including Interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α, were more likely to be increased in patients with HF, and cytokine network activation is one of the main factors for serum CA 125 elevation in patients with CHF dependent on inflammation (36–38). This evidence concerns the gene TNF and congestive heart failure.