Tau35 is a tau fragment that has been described in human brain in progressive supranuclear palsy, corticobasal degeneration and 4R tau-predominant forms of frontotemporal dementia with Parkinsonism linked to chromosome 17, but is absent from the brains of unaffected controls, Alzheimer’s and Pick’s disease patients. Here, MAPT is linked to progressive supranuclear palsy.