IGF1R and neoplasm: Melatonin can also regulate the aforementioned angiogenic miRNAs, and it can upregulate expression of miR-152-3p, “a tumor suppressor found to be downregulated in breast cancer,” which in turn reduces the protein expression of IGF-insulin-like-like growth factor-1 receptor), HI, F-1,α, and VEGF (Marques et al., 2018).