According to recent research, exercise and hormone treatment decreased tumor growth and angiogenesis in a mouse model of invasive breast cancer by reducing levels of miR-21, ER, HIF-1, VEGF, and raising levels of miR-20 IL-10, let-7a, and PDCD4 in tumor tissue (Isanejad et al., 2016). The gene discussed is HIF1A; the disease is neoplasm.