MMP14 and Interstitial cardiac fibrosis: General inhibition of MMPs with PD166793 decreased the total collagenase activity, as well as MT1-MMP activity, and reduced cardiac interstitial fibrosis in Timp2−/−-TAC mice (Table 1) (Kandalam et al., 2011), which is consistent with the finding that reduction of MT1-MMP expression suppressed cardiac fibrosis and improved cardiac function in mice after pressure overload (Table 1) (Zile et al., 2014).