However, local myocardial injection of adenovirus expressing TIMP2 had no significant effect on cardiac fibrosis following MI; although it suppressed the expression and activity of MMP2 and MMP9, infiltration of inflammatory cells, and improved the survival rate and cardiac function to some extent up to 7 days post-MI (Ramani et al., 2011). This evidence concerns the gene MMP2 and myocardial infarction.