TIMP4 and persistent truncus arteriosus: Loss of TIMP4 had no significant effect on descending aortic binding-induced cardiac fibrosis in male mice, but enhanced cardiac fibrosis in a TAC model with both sex which could be reduced by overexpression of TIMP4 (Table 1) (Koskivirta et al., 2010; Yarbrough et al., 2014), suggesting an anti-fibrotic function for TIMP4.