MUC16 and malignant colon neoplasm: Although cancer antigen-125 (CA125) is the most utilized serum-based biochemical marker; its utility as an EOC screening marker is significantly impeded because of high false-positive rate, the lower sensitivity of detection for early stages of EOC, poor specificity as its elevation may also be associated with various benign conditions and several malignancies including lung and colon cancer (Jacobs and Bast, 1989; Woolas et al., 1993).