The median promoter methylation level in tumor DNA of OC patients and normal control subjects was 19.64 (95% CI, 5.17-60.53) and 2.14 (95% CI, 1.46-3.81) respectively for SOX1; 15.10 (95% CI, 3.60-58.28) and 2.97 (95% CI, 2.10-4.20) respectively for RASSF1A; 27.19 (95% CI, 3.13-55.90) and 2.24 (95% CI, 1.48-4.67) respectively for DAPK1; 10.09 (95% CI, 3.93-40.62) and 3.17 (95% CI, 1.78-4.19) respectively for SFRP1 and 10.43 (95% CI, 2.36-44.66) and 3.12 (95% CI, 1.40-5.59) respectively for SPARC (Table 1). The gene discussed is SPARC; the disease is neoplasm.