GRM2 and Alzheimer disease: On the one hand, a clear decrease in anxiety levels was observed when postsynaptic group II metabotropic glutamate receptors (mGluRs) were blocked in mice with AD, specifically mGlu2 and mGlu3 (mGluR2/3), using as a model Dutch mice APP (Alzheimer's amyloid precursor protein E693Q), transgenic rodents that accumulate Dutch amyloid-β (Aβ) oligomers.