Doss et al. (40) demonstrated that the treatment for 21 days with 150 g of BSH in adults with sickle cell disease determined the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in erythroid progenitors and significantly increased the expression of Nrf2 targets such as heme oxygenase 1 (HO-1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), and hemoglobin subunit gamma 1 (HBG1), restoring oxidative capacity. This evidence concerns the gene HMOX1 and sickle cell disease.