Change in FENO (primary outcome), FEV1, FVC, asthmal control test score, rhinitis quality of life score, levels of HO-1, NQO1, GCLC and GCLM, antioxidant gene expression in PBMCs, urinary isoprostane, serum TBARS levels, protein carbonyl levels, IL-4, IL-13, IL-6 levels. This evidence concerns the gene HMOX1 and rhinitis.