Regarding the effect of GSLs on cancer biomarkers, Atwell et al. (53) evaluated the role of SFN on PBMCs histone deacetylase (HDAC) activity, and tissue biomarkers (H3K18ac, H3K9ac, HDAC3, HDAC6, Ki-67, p21) in women with abnormal mammograms and scheduled for breast biopsy. This evidence concerns the gene HDAC3 and cancer.