OCLN and colitis: Both in vitro and in vivo assays have recently shown that after IL-1β administration both Caco-2 cells and enterocytes from mice with colitis display increased small intestinal TJ permeability, a rapid increase in miR200C-3p and reduced levels of OCLN mRNA and protein, meanwhile the antagomiR-200c prevented OCLN and permeability changes (408).