Regarding patients with the septic shock without diabetes, 14 variables, such as age (<0.001), race (p = 0.005), SOFA score (p < 0.001), initial peripheral blood indicators of glucose (p < 0.001), AG (p < 0.001), Scr (p < 0.001), Lac (p < 0.001), BUN (p < 0.001), ALT (p = 0.003), AST (p < 0.001), Tbil (p < 0.001), WBC (p = 0.040), Hb (p = 0.004), and PLT (p < 0.001) were remarkably associated with the 30-day mortality of septic patients without diabetes during the univariate analysis. This evidence concerns the gene GSTM1 and diabetes mellitus.