ACE2 and diabetes mellitus: The following are possible explanations: chronic illnesses such as hypertension, diabetes, and coronary heart disease become increasingly prevalent as people become older (18); the elderly's baseline level of proinflammatory cytokines in tissues and circulation increases with age, and the body's immune response to pathogenic threats or tissue damage is also delayed (19); the angiotensin-converting enzyme 2 (ACE-2) receptor is required for the COVID-19 virus to enter cells (20).