It also agrees with in vitro and in vivo studies in preclinical models [including PLTP-knocked out mice and the infusion of active recombinant human PLTP in mice with experimental sepsis (15, 19, 22, 27)] which have revealed that the PLTP-mediated transfer of LPS to lipoproteins results in neutralization of the pro-inflammatory properties of LPS and in its elimination from the body. This evidence concerns the gene PLTP and Sepsis.