The recirculating capacity of CLA+ memory T cells is key to their value in translational research, due to their ability to reflect the immune abnormalities found in numerous human cutaneous conditions such as psoriasis, atopic dermatitis, contact dermatitis, drug-induced allergic reactions, vitiligo, herpes simplex, rosacea, cutaneous T cell lymphoma, or alopecia areata (14, 15). The gene discussed is SELPLG; the disease is atopic eczema.