Additionally, a proteomic study of plasma samples from 114 non-treated plaque psoriasis patients revealed that, those with higher anti-Candida IgA levels presented increased levels of proteins involved in antimicrobial humoral response, especially proteins showing anti-candida activity [such as eosinophil cationic protein (ECP/RNASE3), Chitinase-3-like protein 1 (CHI3L1) or azurocidin]. This evidence concerns the gene RNASE3 and psoriasis vulgaris.