This study classified the cause of ESRD into five categories: systemic lupus erythematosus, diabetes mellitus (DM), chronic interstitial nephritis, glomerulonephritis, and other factors, including gout, hypertension, aristolochic acid nephropathy, IgA, IgM, and nephritic cystic kidney pathologies. The gene discussed is CD40LG; the disease is diabetes mellitus.