Treatment of Coats' disease should be directed toward obliterating the telangiectasia by laser photocoagulation or cryotherapy (23–25), more advanced cases complicated by severe exudative retinal detachment may require combined therapies such as intravitreal anti-VEGF, or subretinal fluid drainage to facilitate resolution of the exudate or subretinal fluid (26, 27). This evidence concerns the gene VEGFA and Coats disease.