Researchers used the genome-wide atlas to explore promising therapeutic targets of HCC and found that the levels of WBSCR22 and the other five genes (EXOSC4, RNMT, SENP6, RASAL2, and NENF) were much higher in HCC tissues than in adjacent tissues (Li C. et al., 2017). This evidence concerns the gene SENP6 and hepatocellular carcinoma.