AKT1 and hepatocellular carcinoma: Subsequently, CCNB1 increases the ubiquitination of p53 to increase the phosphorylation of PI3K and Akt and reduces the expression of p53 protein, which ultimately facilitates the proliferation of HCC cells by inducing G2/M cell cycle transition, inhibiting apoptosis, and enhancing metastasis and sorafenib resistance via EMT (Liu J. S. et al., 2019).