Although the methyltransferases METTL1, WRD4 and WBSCR22 are closely related to the diagnosis and poor prognosis of HCC, more research is needed to realize the promotion of m7G methyltransferase as a potential therapeutic target and the positioning of RNA m7G methylation to develop a promising targeted intervention strategy. The gene discussed is BUD23; the disease is hepatocellular carcinoma.