In addition, ALKBH5 was reported to inhibit the proliferation and invasion of HCC cells by decreasing insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)-mediated LY6/PLAUR domain containing 1 (LYPD1) RNA stability (Chen et al., 2020). This evidence concerns the gene IGF2BP1 and hepatocellular carcinoma.