Recent studies have reported that abnormally expressed snoRNA-mediated pseudouridylation at the U609 and U863 sites of the rRNA 18S subunit leads to abnormal tRNA selection efficiency, ribosome elongation rate and translation efficiency, thus affecting HCC cell survival; however, the role of DKC1 in the whole process cannot be ignored (McMahon et al., 2019; Nombela et al., 2021). This evidence concerns the gene DKC1 and hepatocellular carcinoma.