In detail, NUS2-mediated m5C modification can enhance the stability of H19 lncRNA, which will motivate the specific binding with the oncoprotein Ras GTPase-activating protein-binding protein 1 (G3BP1) and cause the overexpression of MYC, thus promoting the malignancy of liver cells and leading to the carcinogenesis of HCC. The gene discussed is G3BP1; the disease is hepatocellular carcinoma.