METTL3 and liver cancer: In addition to regulating the mRNA m6A modification, METTL3 has been reported to interact with the DiGeorge critical region 8 (DGCR8) by a m6A modification pattern to boost the maturation of miRNA-873-5p and inhibit the expression of the suppressor with the morphological effect on genitalia 1 (SMG1), thus enhancing the tumorigenicity and malignant phenotype of liver cancer cells (Zhao M. et al., 2020).