Moreover, silencing the reading protein YTHDF2 reduces the degradation of two m6A-modified mRNAs, including interleukin 11 (IL11) and serpin family E member 2 (SERPINE2), which, in turn, escalates the abnormalization of vessels and inflammation and eventually promotes HCC growth, vasculature remodeling and metastasis (Hou et al., 2019). The gene discussed is SERPINE2; the disease is hepatocellular carcinoma.