When assessing the correlation between m1A modifier genes and HCC tumor stage, it was found that high levels of TRMT6, TRMT61A, TRMT10C, ALKBH3, and YTHDF2 are significantly positively correlated with higher tumor stage (G1-G3), which also showed the good evaluation and predictive value of ALKBH3 in the typing and staging of HCC (Wang et al., 2018). This evidence concerns the gene TRMT6 and hepatocellular carcinoma.