Some researchers used The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGALIHC) database to explore the relationship between 10 m1A regulators (TRMT6, TRMT61A, TRMT61B, TRMT10C, YTHDF1-3, YTHDC1, ALKBH1, ALKBH3) and the relevant clinicopathological characteristics, sequencing results, their relationship and the impact of genetic changes on survival; the results showed that high levels of TRMT6, TRMT61A, TRMT10C, and YTHDF1 are closely associated with the poor prognosis of HCC patients, with both AUC1y and AUC3y greater than 0.66 (Shi Q. et al., 2020). This evidence concerns the gene ALKBH3 and hepatocellular carcinoma.