YTHDF2 and liver cancer: In addition, METTL3 was found to accelerate the suppressor of cytokine signaling 2 (SOCS2) mRNA decay via YTHDF2-dependent m6A modification and reduce the level of SOCS2 in malignant tissue, thereby abrogating the inhibitory effect of SOCS2 on liver cancer cell proliferation, migration and stem cell characteristics (Chen et al., 2018).