Additionally, rodent astrocytes exhibit significantly varied expression of many ALS-related genes, are less structurally and functionally diverse, and express a 10-fold decrease in glial fibrillary acidic protein-positive processes than human astrocytes, further limiting translational relevance of this model when studying the role of astrocytes in ALS (Oberheim et al., 2009). Here, GFAP is linked to amyotrophic lateral sclerosis.