For example, 3D hydrogels that incorporate the basement membrane proteins laminin and collagen IV have been shown to support increased contractile force generation in muscle-only (Hinds et al., 2011) and muscle-neuron (Vilmont et al., 2016) culture platforms and uniquely enable tau aggregation in organoid models of Alzheimer’s disease (Choi et al., 2014). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.