LRRK2 and Parkinson disease: Saha et al. (2015) found that LRRK2 G2019S mutation in PD patients led to lysosomal aggregation and inhibition of autophagic activity in dopaminergic neurons. The expression of transcription factor EB (TFEB), an important inducer of lysosomal biogenesis and autophagy (Settembre et al., 2011), is remarkably decreased in nuclei of dopaminergic neurons, and co-localizes with Lewy bodies in samples from PD patients (Decressac et al., 2013).