Interestingly, Wang et al. (2010) found that activation of extracellular signal-regulated kinase, implicated in prostate cancer progression, increased ectopic expression of STEAP2 in AR-negative DU145 cells, but decreased STEAP2 levels in AR-positive LNCaP cells, suggesting a potential interaction between STEAP2 and sex hormones. The gene discussed is AR; the disease is prostate cancer.