It was also found that the expression of STEAP3 is up-regulated in glioma, bladder cancer, and colon cancer (Isobe et al., 2011; Kim et al., 2016; Weston et al., 2016; Han et al., 2018; Zhang et al., 2019), whereas the expression of STEAP3 in hepatocellular carcinoma (HCC), breast cancer, and lung cancer is lower than that in normal tissues (Boelens et al., 2009; Caillot et al., 2009; Savci-Heijink et al., 2016; Cadiou et al., 2017). This evidence concerns the gene STEAP3 and hepatocellular carcinoma.