TSC1 and cancer: Disturbances of the TSC complex lead to mTORC1 hyperactivation and have been linked to diseases including cancer and the clinical manifestations of tuberous sclerosis complex disease (TSC), which are both characterized by cellular overgrowth and aberrant migration (Orlova and Crino, 2010; Borkowska et al., 2011; Curatolo et al., 2015; Henske et al., 2016; Condon and Sabatini, 2019; Jozwiak et al., 2019).