Although, expression of Fgfr4 was significantly increased in AAV-Fgf23 mice compared to Ctrl (Figure 5D), there were no differences in BNP, beta-myosin heavy chain (bMHC), Rcan1, and transient receptor potential cation channel subfamily C member 6 (Trpc6) expression (Figure 5E), all of which are NFAT target genes associated with pathological cardiac hypertrophy. Here, NPPB is linked to cardiac hypertrophy.