In the same regard, cardiac hypertrophy due to elevated phosphate and Fgf23 was reversed by lowering dietary phosphate intake in vivo (Grabner et al., 2017), supporting the hypothesis that cooperative interaction of FGF23 and high phosphate needs to be present for the development of LVH in CKD and non-CKD. The gene discussed is FGF23; the disease is chronic kidney disease.