Cardioprotective properties of klotho have previously been attributed to its suppressive effects on reactive oxygen species, reducing the severity of indoxyl sulfate-induced hypertrophy, and inhibition of Trpc6 as demonstrated in an animal model of stress-induced cardiac hypertrophy (Xie et al., 2012; Yang et al., 2015; Zhu et al., 2017). The gene discussed is TRPC6; the disease is cardiac hypertrophy.