TP53 and esophageal cancer: A high expression of TP53 has been observed in many malignancies (Hinds et al., 1990; Iggo et al., 1990; Samuels-Lev et al., 2001), including esophageal cancer (Huang et al., 2014; Yao et al., 2014; Xie et al., 2017).