As shown in Figure 4, TP53 [hazard ratio (HR) = 0.28 and log-rank p = 0.026] showed a significantly good prognosis in ESCC patients when mRNA expression was upregulated, and TP73 (HR = 2.74 and log-rank p = 0.0043) showed a negative correlation between high mRNA expression and significantly positive OS in EAC patients. The gene discussed is TP73; the disease is esophageal squamous cell carcinoma.