As shown in Table 1, high mRNA expression of TP53 in ESCC was positively correlated with TNM stage (p = 0.007) and lymph node metastasis (p = 0.030) in ESCC patients, while no association was observed with other clinicopathological features, including age, gender, and differentiation. This evidence concerns the gene TP53 and esophageal squamous cell carcinoma.