MGMT and glioma: On the other hand, the high proportion of CAF is mainly enriched in glioma patients with higher age (P < 0.0001), high WHO grade (P < 0.001), IDH wildtype status (P < 0.001), 1p/19q non-codeletion status (P < 0.001), and MGMT promoter un-methylated status (P < 0.01).