TNF and neoplasm: It was revealed that the main enriched pathways in the tumor, including epithelial-mesenchymal transformation (Shintani et al., 2016), hypoxia (Lappano et al., 2020), inflammatory Response (Ershaid et al., 2019), interferon-gamma response (Broad et al., 2021), and NFkB-mediated TNFα signal transduction (Katanov et al., 2015) were closely related to the function of CAFs.