In homo genome, the aberrant expression of PRDM8 (PR domain containing 8) is closely related to down syndrome (DS); the PRDM8 is transcribed as two different transcripts, which are regulated by an internal promoter in PRDM8, leading to a significantly improved expression of transcript variant two in DS patients (Lu et al., 2016). Here, PRDM8 is linked to Dravet syndrome.