CD4 and colorectal carcinoma: This study proved that tertiary lymphoid structures (TLSs) defined by a high density of CD3/CD4 T cells, B cells, CD163 macrophage, and CD4/CD45RO T cells are associated with better clinical outcomes for Crohn’s-like reaction (CLR) phenotype, whereas PD-1/CD4 expression T cells in granulocyte defined neighborhood positively correlated with survival in diffuse inflammatory infiltration (DII) subtype of CRC (Schurch et al., 2020).