AGT and abdominal aortic aneurysm: Neutralizing antibodies is a widely used method to inhibit the function of the target antigen; program death-1 (PD-1) antibody can neutralize PD-1 function to decrease neointimal hyperplasia and aneurysm formation in rats (Bai et al., 2021b; Sun et al., 2021a; Sun et al., 2021b), systemic blockade of TGF-β by neutralizing antibodies can accelerate abdominal aortic aneurysm development in angiotensin II-infused mice (Angelov et al., 2017).