TNF and ocular melanoma: Allelic association studies have identified polymorphisms related to the development of OM in genes encoding TLR4 receptors, IL-6, IL-10 and TNF-α (Emonts et al., 2007), mannose-binding lectins (Wiertsema et al., 2006), surfactant (Ramet et al., 2001), and Mucin gene MUC5AC (Ubell et al., 2010) [for review see (Mittal et al., 2014a; Lin et al., 2017; Geng et al., 2019)].