TLR4 and ocular melanoma: The inability of this study to replicate the association of a previously unrecognised TLR4 haplotype in two independent Finnish cohorts with UK or 2 US cohorts emphasises the potentially heterogenous nature of OM and the complexity of environmental and host factors that may modulate overall susceptibility to OM (Hafren et al., 2015; Einarsdottir et al., 2016).