The αvβ3 and αvβ5 integrins are well-studied integrins that are upregulated in the tumor microvasculature and in many tumors as well, where they are likely to engage provisional matrix consisting of vitronectin, fibronectin, osteopontin, fibrinogen and von Willebrand factor in the tumor microenvironment (7). Here, VWF is linked to neoplasm.