The present study found that a majority of solid tumors have decreased MARCO expression compared with controls, including bladder cancer, colon cancer, cholangiocarcinoma, lung cancer, HCC, ovarian cancer, prostate cancer, breast cancer, adrenocortical carcinoma, esophageal cancer, gastric cancer, endometrial cancer, and uterine sarcoma. The gene discussed is MARCO; the disease is hepatocellular carcinoma.