“Don’t eat me” signaling pathways, such as CD47-SIRPα, the MHC-I-LILRB1 axis, and the CD24-SIGLEC-10 axis can be expressed by all types of macrophages (48) and play crucial roles in inhibiting macrophage phagocytosis of tumor cells in numerous cancer types (13, 15, 17, 29). The gene discussed is SIRPA; the disease is cancer.