For example, antibodies directed against specific tumor fusion proteins or chimeric antigen receptor T cells (CAR T cells) provide specific and active immunity against specific cell types or tumor neoantigens, while checkpoint blockade inhibitors such as anti PD-1/PD-L1 or anti-CTLA4 increase the overall activity of the T cell response which consequently increases anti-tumor immunity (117). This evidence concerns the gene CTLA4 and neoplasm.