JAK-STAT activation by IFNs is also important for T cell activation and differentiation (20), and aberrant signaling along various IFN-JAK-STAT axes is known to contribute to the pathogenesis of many autoimmune diseases (21) and irAE such as myocarditis due to anti-PD-1 therapy (22). The gene discussed is SOAT1; the disease is myocarditis.