Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase that catalyzes histone H3 lysine 27 trimethylation (H3K27me3) and epigenetically silences target genes (10), is overexpressed in many cancer types and has been shown to act as an oncogene (11, 12). The gene discussed is EZH2; the disease is cancer.