Based on the basic biological properties of MALAT1, more and more studies have shown that it can be used as a bait for miRNA to share miRNA response elements (MREs) with mRNAs, which indirectly affects the expression of some specific downstream genes, thus promoting the proliferation, invasion, apoptosis, drug resistance, and tumor growth of NSCLC. This evidence concerns the gene MALAT1 and neoplasm.