ESR2 and non-small cell lung carcinoma: Because miR-145-5p directly targets the 3′-UTR of the neural precursor cell expressed, developmentally downregulated 9 (NEDD9) mRNA, increasing the expression of MALAT1 can indirectly upregulate the protein expression of NEDD9. Further experiments showed that ERβ could promote the vasculogenic mimicry (VM) formation and cell invasion of NSCLC by the ERβ/MALAT1/miR-145-5p/NEDD9 signaling pathway (51).