It is well established that 70–80% of ARMS cases harbor chromosomal translocations t(2;13)(q35;q14) or t(1;13)(p36;q14), which generate paired box (PAX)3-forkhead box O1 (FOXO1) and PAX7-FOXO1 fusions, respectively. This evidence concerns the gene FOXO1 and alveolar rhabdomyosarcoma.