KDM4C and breast cancer: KDM4C upregulates many genes responsible for cell growth, migration, and metastasis and interacts with HIF-1α, mediating KDM4C recruitment on hypoxia-inducible genes and demethylation of H3K9 on metabolic genes, such as LDHA, PDK1, LOXL2, L1CAM, BNIP3, and GLUT1. The physical interaction of these two proteins is a critical epigenetic mechanism, given that HIF-1α involvement in BC is responsible for an aggressive phenotype, characterized by metastasis progression and resistance to drug therapy (83).