This dissimilar interaction might be explained by the difference in cell lines and drug doses used in the studies: while we chose SKOV3, A2780PAR, A2780CR and OVCAR3 cell lines to represent BRCA wild type serous ovarian cancer, and SNU251 which is an endometroid ovarian cancer cell line that was previously reported to carry a nonsense mutation at amino acid 1815 of BRCA1. Pillay et al. The gene discussed is BRCA1; the disease is ovarian serous adenocarcinoma.