BRCA2 and breast cancer: Lastly, Gogola’s group used two types of in vitro cultures that they derived from BRCA2 -/-; Trp53-/- mouse mammary tumors from K14cre;Trp53F/F;BRCA2F/F (KB2P) mice: two-dimensional (2D) tumor cell lines (KB2P1.21,KB2P3.4) and three-dimensional (3D) cancer organoids (ORG-KB2P26S.1).