Surprisingly, p53 activation was found to modulate ferroptosis (64, 65, 67) but had no significant effect on GPX4 function, while Chu et al. (68) found that arachidonate 12-lipoxygenase (ALOX12) (68, 69) inactivation attenuated p53-mediated ferroptosis induced by ROS substances and promoted the rapid growth of p53-dependent tumors in xenograft tumor models, suggesting that ALOX12 gene may be critical for p53-mediated ferroptosis. The gene discussed is ALOX12; the disease is neoplasm.