Notably, in pre-clinical in vivo T-ALL models generated by overexpression of the intracellular cleaved form of Notch1 (ICN1), CCR7 overexpression led to enhanced chemotaxis and invasion into different tissues, especially to leptomeningeal spaces of brain and spinal cord, in which endothelial cells were shown to produce CCL19 (25). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.