CCR7 overexpression, as mRNA (14, 32–34) and as surface protein (in comparison to normal pan-B-cells and CD5+CD19+ B-cells), is consistently found in virtually all CLL, irrespective whether sampled from PB, BM, or LN (13, 19, 21, 35–48). Here, CD5 is linked to B-cell chronic lymphocytic leukemia.