Two studies in a total of 41 ALCL patient samples and in 7 ALCL cell lines found the anaplastic-lymphoma kinase (ALK)-negative ALCL variant to overexpress CCR7 genes (compared to ALK-positive or primary cutaneous ALCL) (116, 189) while another series on LN biopsies associated ALCL to a CD4+CD45RO+CD27- TEM phenotype that lacks CCR7 (190). Here, CD4 is linked to anaplastic large cell lymphoma.