CCR7 and acute lymphoblastic leukemia: In T-ALL, CCR7 expression is controlled by the activity of the oncogene Notch1. Significantly up-regulated CCR7 was found in human T-ALL cells that harbor Notch1-activating mutations while receptor expression was repressed by Notch1-specific γ-secretase inhibitors (DBZ or compound E), both at mRNA and at protein levels (25).