NFKB1 and B-cell chronic lymphocytic leukemia: Moreover, constitutive activation of the Notch1 oncoprotein increases CCR7 expression in T-ALL through the mTORC2/NF-κB cascade (25, 133), or in CLL through down-modulation of the DUSP22 phosphatase levels and the subsequent increase in STAT3 activation (51).