For example, tonic signaling through the BCR or CD40 activates transcription factors such as NFATC1, NF-κB, and AP-1, which target the CCR7 gene, a mechanism found in CLL and B-ALL (22, 23, 42, 54–56, 208, 211). Here, NFATC1 is linked to B-cell chronic lymphocytic leukemia.