Nevertheless, some associations of CCR7 expression with markers of disease subsets, hence aggressiveness or outcome, might be of indirect nature and just represent indicators of different inherent cellular programs (e.g. higher migratory potential), as suggested for the histogenetic subsets of CLL with unmutated IGHV and/or with trisomy 12 that show higher responsiveness to CCR7 ligands (35, 36, 38, 46, 47, 66). Here, CCR7 is linked to B-cell chronic lymphocytic leukemia.