The importance of this cross-talk was demonstrated by showing that genetic deletion of CCR7 impaired lymphoma growth (9). Therefore, this model not only established the basis for a better understanding of the pathogenic role of CCR7 in BL, but also in many other blood cancers with a high dependence on the nodal or splenic microenvironments. The gene discussed is CCR7; the disease is hematopoietic and lymphoid system neoplasm.