Recently, Legler et al.have shown on trisomy-12 carrying OSU-CLL cells that CCR7-mediated inside-out signaling to the β1 integrinVLA-4 and the β2 integrin LFA-1 is controlled by Src and ZAP-70 kinases (58, 63). Here, ITGAL is linked to B-cell chronic lymphocytic leukemia.