In this context, synergisms between CCR7/CCL19 and CXCR5/CXCL13 were shown to mediate resistance of B-ALL cells to tumor necrosis factor alpha (TNF-α)-mediated apoptosis through activation of paternally expressed gene 10 (PEG10) (26, 27). The gene discussed is TNF; the disease is acute lymphoblastic leukemia.